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Off-target effects

Off-target effects occur when the genome editing tool, such as CRISPR-Cas9 system, cuts DNA at unintended locations in the genome. This can potentially cause unwanted genetic modifications, such as insertions or deletions at the wrong site.

 

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This entry was provided by the doctoral students of the GetRADI collaborative network. GetRADI is funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

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