The epithelial of the skin and intestine epithelia rely on stem cells for their constant and life-long replenishment. It remains unknown when and how these stem cell first appears during development, how stem cell behaviour is regulated during steady state homeostasis, and to what extent these regulatory mechanisms are altered during regeneration and disease. Insight into these questions will be pivotal for a mechanistic understanding of tissue maintenance, establish cell sources for regenerative therapies and identify new therapeutic targets.
The main objective of the Jensen group is using state-of-the-art quantitative approaches to address these outstanding questions.
