Prime editing is a genome editing technique that combines the precision of CRISPR-Cas9 with a modified Cas9 enzyme. This modified enzyme is fused to a reverse transcriptase to make highly accurate changes to DNA, by converting a genetic instruction from RNA to DNA and inserting that genetic information at a specific and programmable location in the genome. It allows scientists to insert, delete, or replace specific DNA sequences in the genome with minimal errors, offering great potential for treating genetic diseases.
This entry was provided by the doctoral students of the GetRADI collaborative network. GetRADI is funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.