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Actors and Networks database

The evolving field of gene and cell therapy is supported by a large community of academic, clinical, translational, regulatory and patient organisations. The Actors and Networks database maps these stakeholders in Europe and beyond, their activities, and resources they have produced. 

EuroGCT has developed and compiled this database for those interested in identifying the actors involved at each stage of the pathways bringing gene and cell therapies from lab to clinic. Coming from an academic perspective, our focus is to map information that has not been mapped elsewhere. This includes documenting the various types of interconnected regulators, patient groups actively involved along the pathways, and non-profit organisations devoted to therapy development. In its first iteration, this database does not yet include commercial partners and service providers.

Additional complementary work by other organisations on GCT stakeholders mapping can be found here.

A scientific paper on actors has also been published in Humanities and Social Sciences Communications. You can find its lay summary here.

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European Commission (EC / COM)

Type of Actor:

  • Regulators
  • Medicines Agencies
  • Supranational Medicines Agencies
  • Research Funding Authorities
  • Supranational Research Funding Authorities

Development Stage:

  • Fundamental Research
  • Translational Research
  • Clinical Research

Additional information

The European Commission is not a medicines agency as such. However, under the centralised procedure applicable to advanced therapy medicinal products, it is the sole authority competent for granting marketing authorisations following their evaluation by the EMA. / Regarding its funding role, the Commission funds research through programs and open calls that support research and innovation projects, with links to open and upcoming calls. The research and innovation programs include but are not limited to: Horizon Europe with a budget of €95.5 billion for 2021-2027, EU4Health, Cohesion fund, LIFE Climate Change Mitigation and Adaptation. The European Commission also funds individual research.

European Data Protection Board (EDPB)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Data Authorities
  • Supranational Data Authorities

Development Stage:

  • Fundamental Research
  • Clinical Research
  • Translational Research
  • Health Data

European Data Protection Supervisor (EDPS)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Data Authorities
  • Supranational Data Authorities

Development Stage:

  • Fundamental Research
  • Clinical Research
  • Translational Research
  • Health Data

European Health and Digital Executive Agency (HaDEA)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Research Funding Authorities
  • Supranational Research Funding Authorities

Development Stage:

  • Fundamental Research
  • Translational Research
  • Clinical Research

Additional information

The HaDEA manages European programs and initiatives on behalf of the European Commission to support research and implements actions that strengthen Europe in the domains of health, food safety, digital technologies and networks, industrial capacities and space. It works closely together with five Directorates-General (DG CNECT, DEFIS, GROW, RTD and SANTE which is the lead DG for HaDEA) and with the Commission’s European Health Emergency Preparedness and Response Authority (HERA), which are focusing on legislative and strategic tasks in policy making.

European Joint Programme on Rare Diseases (EJP RD)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Networks
  • EU Research Projects
  • Training Providers
  • Medicines Research and Development
  • Patient Involvement

Development Stage:

  • Fundamental Research
  • Clinical Research
  • Translational Research
  • Manufacturing
  • Commercialisation

Conditions and Diseases:

  • Rare diseases

Additional information

Bringing over 130 institutions from 35 countries, EJP RD aims to create an effective, comprehensive, and sustainable rare diseases research ecosystem.

European Medicines Agency (EMA)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Medicines Agencies
  • Supranational Medicines Agencies

Development Stage:

  • Fundamental Research
  • Clinical Research
  • Translational Research
  • Manufacturing
  • Commercialisation

Additional information

EMA is a decentralised agency of the European Union (EU) responsible for the scientific evaluation, supervision and safety monitoring of medicines in the EU.

European Network of Research Ethics Committees (EUREC)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Ethics Committees
  • Supranational Ethics Bodies

Development Stage:

  • Fundamental Research
  • Clinical Research

Additional information

EUREC is a network that brings together already existing national Research Ethics Committees (RECs) associations, networks or comparable initiatives on the European level.

European Patent Office (EPO)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Patent Offices
  • Supranational Patent Offices

Development Stage:

  • Fundamental Research

European Patients' Forum (EPF)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Patient Organisations
  • European Patient Organisations

Development Stage:

  • Clinical Research
  • Translational Research
  • Commercialisation
  • Patient and Public Involvement

Additional information

EPF is an independent non-profit, non-governmental umbrella organisation of patient organisations across Europe and across disease-areas

European Research Council (ERC)

Region/Country:  
  • EU/EEA

Type of Actor:

  • Regulators
  • Research Funding Authorities
  • Supranational Research Funding Authorities

Development Stage:

  • Fundamental Research
  • Translational Research
  • Clinical Research

Additional information

Set up by the European Union in 2007 and Established by the European Commission, the ERC is the first European funding organisation for excellent frontier research. It funds creative researchers of any nationality and age, to run projects based across Europe. The ERC Executive Agency (ERCEA) is in charge of implementing and managing the daily operations of the European Research Council. The ERC is part of the Horizon Europe program and has therefore a budget of more than 16 billion for 2021-2027. The ERC is led by an independent governing body, the Scientific Council.

Resources

"ERC at a Glance | European Research Council Overview: https://erc.europa.eu/about-erc/erc-glance; ERC President & Scientific Council: https://erc.europa.eu/about-erc/erc-president-scientific-council; ERC Executive Agency (ERCEA): https://erc.europa.eu/about-erc/erc-executive-agency
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